Human growth hormone is the most cherished subtle in the world of bodybuilding. Can build muscle mass and burn fat at the same time. Moreover, it maintains the health of the bones and joints. But the cost of an effective HGH cycle is huge, and some serious side effects may also occur.
In the human body, growth hormone (HGH) is produced by the pituitary gland. It is found in very large quantities during adolescence, when it promotes tissue generation, protein storage and consumption of subcutaneous tissue. With age, the endogenous levels of this hormone decrease constantly, remaining in the body in very small amounts, with very little visible effects. In the body, the structure of the growth hormone is composed of a sequence of 191 amino acids.
Before the pituitary gland releases growth hormone, hormone releasing growth hormone and somatostatin are released by the hypothalamus, and they are the ones that determine the amount of growth hormone released by the pituitary. There are many factors that influence the release of growth hormone, including nutrition and training.
After being isolated by scientists, it has been proven that this hormone has fantastic therapeutic properties, especially in the case of pituitary glandular deficiency.
It was first isolated in 1956, and its structure was identified in 1972. In the 1980s, the first drugs containing growth hormone appeared. The only source of growth hormone was the pituitary gland of human corpses. But this method of producing drugs had a short life, because because of these drugs patients could infect a very rare disease of the brain, the disease that was fatal. Today, all growth hormone releases are synthetic. It's almost impossible to find old products such as Grorm on the market.
The use of growth hormone has spread more and more in the sport world due to its many beneficial effects. Its promoter (as is the case with many other substances used today in bodybuilding) was Dan Duchaine.
Growth hormone is a protein that stimulates body cells to grow in size but also to divide more rapidly, increasing their number. It improves the passage of amino acids through the cell membrane, and increases their rate of conversion to proteins. In other words, it creates an anabolic environment in the body. Moreover, growth hormone decreases the rate at which cells use carbohydrates for energy, favoring the use of fats. Thus, growth hormone builds up muscle mass while burning fat.
Increases in growth hormone include skeletal muscles and other organs outside of the eye and brain.
How Much Is Anabolic Growth Hormone? In one study, athletes at rest, who used HGH, were in an anabolic state. In other words, you can run marathons and build muscles.
Growth hormone is released by the pituitary gland by rhythmic pulses, during sleep, by two peptides: the hormone releasing growth hormone and somatostatin. These two peptides are secreted in turn. As you can imagine, the hormone releasing growth hormone is responsible for stimulating the pituitary gland (logically!).
Growth hormone can also stimulate cartilage recovery and enhancement (an advantage for those who work with very heavy weight). But for this process, a somatomedin (IGF - insulin-stimulating growth factor) that is secreted from the liver in response to growth hormone is needed. IGF is the one that promotes the repair of cartilage. The most elevated levels of IGF-1 occur 20 hours after growth hormone administration.
Even if HGH needs IGF to restore cartilage, it may be the only way to increase the length of the bones; has a beneficial effect on erythropoietin, which influences even more anabolism and endurance.
As there is negative feedback on anything in the body, so is the case with growth hormone; and involves the IGF. When the liver secretes IGF-1, a signal is transmitted to the hypothalamus and the pituitary gland to stop growth hormone production.
Now something interesting: even if growth hormone is a good muscle builder and a good fat burner, it's a bad choice when it comes to increasing strength. It may seem illogical, those who use it to the contrary. But it is usually used with anabolic and androgenic steroids and other stimulant substances, with increasing strength from these.
Although there is its use in the sport world, there are no tests to detect HGH by urine analysis. The only way to detect HGH is by harvesting blood.
The extent to which HGH helps an athlete has been the subject of a long dispute. Some say it is the most anabolic substance, capable of amazing things, giving muscle mass gains and fat burning in very short periods of time. Because it is only used by professional competitors who can afford such expensive substances, an even greater aura of mystery surrounds HGH. Many say the "tons" of muscles presented to Mr. Olympia by competitors are 100% due to the use of growth hormone. There are also those who say it is a waste of money and time, that it does not have anabolic properties and the high price makes it totally useless in the face of steroids. With so many shared opinions, who should we believe?
First we need to understand why the results vary so much. It seems the most logical is the extremely high price. The technology by which it is produced is being produced, the production costs are high, and it is as if an athlete can cost him impressive amounts of HGH per day. Estimating a price is irrelevant, prices are changing often, but it's about a lot of money. Most do not allow such amounts and compensate for small doses. This will result in very small or no effects. If you do not allow a full cure of HGH, you should not try at all. The high cost is mainly due to the fact that the growth hormone's efficiency is seen over a long period of time, from 4 months upwards. Many claim that only two months later its effects begin to be visible. There are many who use it for 6 months, even for one year.
Growth hormone administration
Doses are 2-6 U.I. (international units) to achieve the best results, but they are also people who use higher doses. But the ideal dose is calculated according to the weight of each. The most used doses by athletes are 2 - 4 U.I. It was thought that daily administration is very important because HGH has a low life span. But further studies have negated this hypothesis. The best way to administer is one day yes no. This improves the natural growth hormone release pulses and avoids over-saturation of the receptors, which results in better long-term results.
The most appropriate is to administer one day yes no one; on the day it is given, it is done in two halves, in the morning after waking up and in the evening before bedtime. The optimal dose for administration is 0.028 IU / kg body weight. So someone who weighs 90 pounds will administer about 2.5 U.I. twice a day for a total daily dose of 5 U.I.
Maximum blood concentration occurs 4-6 hours after injection and has a half-life of 30 minutes. Clearly, this will make it difficult to maintain HGH levels in the blood. Effects are also more pronounced when used for long periods of time, often several months. It can also be used for shorter periods, but especially when looking for fat loss. For this, a cycle of at least 6 weeks should be followed. Generally it has a slow action and results as visible as it can be seen after 8-12 weeks.
It may be administered intramuscularly or subcutaneously (the latter being the most commonly used). The subcutaneous route has a 75% absorption and an intramuscular dose of 63%. Subcutaneous injection also leads to the loss of fat where it is done, which necessitates changing the injection site every time for a symmetrical body look. It seems most agree when it comes to the fat burning properties of HGH. They are the most pronounced and they see themselves as quickly as possible, and very high doses are not needed.
Other substances can be used concurrently with growth hormone for the best effects. It seems that the body also needs a greater amount of thyroid hormones, insulin and androgens, when levels of HGH are high. To begin with, the addition of thyroid hormones will increase the thermogenic effect of the cycle. Cytomel or Synthroid (T3 or T4) can be given. And insulin is welcome in such a cycle, especially for its anabolic precursors. Steroids are also needed for HGH to reach its anabolic potential. An androgen is preferred, such as testosterone or trenbolone. The androgen effect is welcome because it promotes anabolism in ways other than those of growth hormone. This combination of HGH, anabolic, insulin and T3 is very synergistic, being the best method to accumulate muscle mass and lose body fat. However, it should be taken into account that thyroid hormones and insulin are strong substances that involve some additional risks. Strong and risky combinations like the above are not recommended to professionals, much less to amateurs, and in no case to specialist supervision.
Side effects of growth hormone
Growth hormone also comes with some side effects that may occur, depending on the sensitivity of each. Thinning or thickening of the bones, especially in the hands, feet and forehead; increasing internal organs; hypoglycaemia due to induction of insulin resistance; carpal tunnel syndrome. However, these risks are low, and such problems are rarely reported among athletes who use moderate doses, even if they do it regularly and for long periods of time. But if a change in bone structure, skin texture or other alarming signs is observed, administration should be discontinued forever.
And gynecomastia or fluid retention is possible with the use of growth hormone. In fact, a common side effect is water retention around the ankles and wrists, along with joint and head pain. They appear especially at the beginning of the cycle and gradually disappear.
Other side effects that may occur include: reduction of thyroid hormone levels, nausea, dizziness, respiratory infections, skin numbness.
Another possible effect is the irritation of the injection site and the appearance of small swelling. Many inject their growth hormone into the abdomen, being the only hormone that can cause local fat burning. Growing hormone abuse, using high doses or using it for a long time can increase your hands, legs, jaws and internal organs. It can also cause type II diabetes due to increased insulin resistance.
First of all, we need to realize that a short cycle with HGH is very expensive. And this is not unparalleled because it is the best anabolic but because the manufacturing process is complex and costly. If you have 1,000 euros to spend to gain muscle, you better give steroids. Growth hormone is a tool for those who want to get more than just can with anabolic steroids. It is usually used by professionals who can afford to spend such amounts. And always in combination with other substrates, not just HGH alone. The money spent on growth hormone is justified in professional circles, where the competitors win their everyday life through their physics, so they can be seen as an investment. Outside of the professional arena, these expenses are useless unless you have a large wallet.
Do not misunderstand me, growth hormone is effective; just that there are no compromises. Either you are willing to spend as much as you need to lead a cycle to the end, or you are heading for something else! Dose reduction and shortening cycles are not viable options.
Because of the high price, there have been many fakes of growth hormone. Much of what is on the black market is actually HCG "dressed" in HGH packaging. Such products can be detected by a pregnancy test purchased from the pharmacy. These tests work by detecting HCG in the urine present during pregnancy. In the case of
we want to find out if HCG is in our HGH ampoules. After a week of starting the cycle, inject 1 ml of growth hormone before bedtime. When you wake up, do the pregnancy test. If it comes out positive it means you have been fooled and you actually take HCG and not a growth hormone.
Growth hormone (like HCG) is packaged in two separate ampoules, one containing a sterile solution, the other one powder. The contents of the two ampoules are mixed before being injected. Synthetic growth hormone is perishable, and should be refined.